The Organization for Economic Cooperation and Development (OECD) has played a critical role in shaping global economic norms, policies, and regulatory frameworks since its establishment in 1961. The OECD has evolved into a multilateral institution that seeks to promote economic cooperation, trade liberalization, and sustainable development. Over the decades, its membership has expanded to include key economies beyond its original Western-centric base, reflecting its strategic adaptation to shifting geopolitical and economic realities. Türkiye, as a founding member, has actively contributed to the OECD’s agenda, particularly in addressing the Global North-South divide and fostering inclusive international dialogue. This commentary examines the OECD’s role in global governance, analyzing its institutional strengths, limitations, and the strategic engagement of significant countries like Türkiye. The study explores how the OECD navigates contemporary challenges such as digital transformation and artificial intelligence regulation while assessing Türkiye’s positioning within these multilateral policy frameworks.